06 September 2017

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Weight Loss DNP is it suitable for Human Consumption

Weight Loss DNP is it suitable for Human Consumption

This article covers following
a-What is DNP and side effects of DNP
b-Is DNP suitable for Human Consumption?
c-DNP and Weight Loss, is it safe to use DNP for Weight Loss?
d- History of DNP

What is DNP?
2,4-Dinitrophenol or simply DNP, is an active compound that essentially disrupts normal cellular respiration.

Nowadays, DNP is sold mostly over the internet under a number of different names such as ‘DNP’, ‘Dinosan’, ‘Dnoc’, ‘Solfo Black’, ‘Nitrophen’, ‘Aldifen’ and ‘Chemox’.

The chemical is a yellow crystalline powder that has a sweet, musty odour and is soluble in water. The dose of DNP per capsule varies from website to website but it is most commonly sold as either 100- or 200-mg capsules.

Some internet sites have DNP available in bulk quantities, allowing users to purchase kilograms of DNP powder or hundreds/thousands of DNP-containing tablets, as well as offering free anabolic steroids and thyroxine to use in combination with the DNP

DNP is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions.

DNP is a synthetic chemical product which can induce very rapid fat loss when taken orally. It accomplishes this by dangerously increasing body temperature and metabolic rate.
DNP as the harshest and most dangerous drug used in bodybuilding.

2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects.

DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century.

The first death due to DNP (C6H4N2O5) was reported in 1918 and was secondary to occupational exposure

Physical Properties of DNP -
The chemical formula for 2,4-dinitrophenol is C H N O and the molecular weight is 184.11 g/mol.
2,4-Dinitrophenol exists as yellowish crystals, is slightly soluble in water, and is volatile with steam. 

History of DNP or Dinitrophenol

2, 4-Dinitrophenol, or DNP is a weight loss drug that has been banned since 1938.

The French used DNP in the manufacture of munitions during the First World War
Since then, it has also been used as a dye, wood preserver, herbicide and photographic developer.

DNP was first used on an industrial scale in French munitions factories during the first world war when it was mixed with picric acid to make explosives. The experiences of workers exposed to DNP highlighted both its potential and its risks. They lost weight, they felt fatigue, sweated excessively and exhibited elevated body temperature. Many deaths occurred before safety measures were introduced.

It was Maurice Tainter at Stanford University in 1933 who discovered that the human consumption of DNP led to significant weight loss and soon it was popularized as a weight loss drug

It was included in over-the-counter medications and was sold to the public without requiring a prescription.

Its use for those wishing to lose weight was encouraged by reports of rapid, safe weight loss
DNP can cause a significant increase in the basal metabolic rate This leads to weight loss by burning more fat and carbohydrates and weight loss of up to 1.5 kg per week is reported without significant side effects. However, there seems to be significant variation in individual responses with an average metabolic rate increase of 11% for every 100 mg of DNP when taken regularly [10–12]. As more side effects, especially cataracts, were reported, DNP was labelled as ‘extremely dangerous and not fit for human consumption’ by the Federal Food, Drug and Cosmetic Act of 1938

After 1938, medical prescription of DNP stopped and cases of poisoning due to medical intake were no longer reported, but case reports of deaths associated with the ingestion of DNP still emerged It is anecdotally reported to have been prescribed to the Russian soldiers during World War II to keep them warm

In 1981, a physician (Dr. Bachynsky) in TX, USA processed industrial DNP into tablets which he marketed/dispensed under the trade name ‘Mitcal’ through his private weight loss clinic He advertised that weight loss occurred using ‘Mitcal’ through a mechanism he called intracellular hyperthermia therapy.

It is alleged in subsequent court proceedings that over 14,000 people were treated by Dr. Bachynsky. Individuals using Mitcal started reporting adverse effects, such as fever, shortness of breath and sweating, to the US Food and Drugs Administration in late 1982. Additionally, there was a fatality associated with an intentional overdose of ‘Mitcal’ in 1984.

Following further investigation, Dr. Bachynsky was convicted in 1986 of drug law violations, fined and prohibited from dispensing DNP to any patients. However, he continued to use DNP for a variety of different ‘medicinal claims’ and was eventually jailed for fraud in 2008 in the USA in relation to the marketing of a company that was developing DNP being used in Europe as a cancer treatment known as intracellular hyperthermia therapy

The UK Food Standard Agency issued a warning in 2003, labelling DNP as ‘not fit for human consumption’. This warning was aimed specifically at bodybuilders, to avoid its use due to significant potential for short-term and long-term harm, following the hospitalisation of a Finish bodybuilder after having taken DNP

How Does DNP work?
In 1948, Harvard biochemists W F Loomis and Fritz Lipmann showed that DNP disrupts energy generation in cells. Normally, the energy required for driving the multitude of processes that occur in cells comes from the oxidation of food (fat and carbohydrate). In the presence of DNP, fat and carbohydrate in food are broken down but production of useful energy for cells is impaired and is instead released as heat. As a result, body reserves of fat and carbohydrate are mobilized and weight is lost.

Side Effects of DNP?
Following are the side effects of DNP
2-Tachycardia- irregular and rapid heart rate
3-Rapid breathing
6-Dizziness and headaches
7-High temperature, Intense sweating and flushed skin
8-Nausea and vomiting
9-Yellow bodily fluids
10-water retention
12-reduction of insulin production

DNP is now available via the internet and is being used without supervision or regulation.
One can easily buy the DNP as he wants but one should avoid using DNP for weightless.

DNP has legitimate uses in areas such as biochemical research and in manufacturing chemicals. For this reason, DNP is not illegal for sale but it is illegal where sold for human consumption. However, the highly toxic 'fat burning' substance continues to be sold in capsules and powders, and continues to be consumed. This can and does kill.

DNP is an industrial chemical that is not fit for human consumption.

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Wednesday, September 6, 2017

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