History Timeline of Stem Cell Cord Blood Banking
History Timeline of Stem Cell Cord Blood Banking
Below is brief history of cord blood banking
1950
Scientists describe function of HLA antigens.
1966
Canadian physicians document blood cell production mechanism of bone marrow (BM)
1974
First bone marrow transplants performed; compatibility increased via HLA tissue typing.
1974
First report on human umbilical cord blood (CB) stem cells.
1980
Similarities found between human CB and BM.
1982
Research confirms that CB contains hematopoetic stem cells suitable for transplantation.
1983
CB stem cells suggested as alternative to BM for transplant.
1988
First successful CB transplant in 6 yr old boy with Fanconi’s Anemia, using sibling’s CB (France).
Bone Marrow Donors Worldwide develops global search engine where donors register and publish their HLA type for matching purposes.
1992
New York Blood Center establishes first public CB bank.
1993
Bone Marrow Donors Worldwide registers first public CB bank. To date, over 200,000 CB units from 39 cord blood banks and 21 countries are available for transplantation.
1993
First unrelated CB transplant performed (Duke University, USA).
1995
First family cord blood bank opens (USA).
1996
National Health Service (UK) establishes public CB bank.
1996
Canadian provincial government helps establish Alberta Cord Blood Program public bank.
Long-term provincial funding still required.
1997
Cells for Life opens in Ontario as one of Canada’s first family banks.
1997
46 yr old man with chronic myelogenic leukemia successfully treated with CB stem cell transplant.
1997
Data shows one-year survival rate is doubled if patient receives CB stem cell transplant from a
relative (63%) vs unrelated donor (29%).
1998
New York Cord Blood Center publishes outcomes of first 562 cord blood transplants from unrelated donors.
1998
American Association of Blood Banks (AABB) accredits first family bank.
1998
First successful transplant to cure sickle cell anemia.
1998
Research shows CB transplants result in significantly lower instances of graft vs host disease.
2001
Research confirms CB is a suitable alternative to BM for adults requiring stem cell transplant.
2002
Cells for Life establishes first Medical Need Program in Canada, providing free processing/storage to parents requiring child’s CB sample for medical treatment.
2002
Hema-Quebec initiates public cord blood banking project funded by the QC government. To date, Hema-Quebec has ~ 500 samples stored.
2003
Japan uses CB in more than half of all transplants (children and adults).
2004
George W. Bush allocates $10 million to establish National Cord Blood Stem Cell Bank Program; instructs Institute of Medicine (IOM) to study the development of a national cord blood public bank program and CB research plan.
2004
New England Journal of Medicine article states that cord blood stem cells are acceptable treatments for adults with leukemia.
2004
Illinois becomes first US State to mandate that all expectant mothers have the option to donate baby’s CB to a public bank at no cost; many States legislate that doctors must provide education on cord blood banking options
2005
Canadian Hematology Society and the Canadian Blood and Marrow Transplant Group officially support the development of a Canadian National Public Cord Blood Program. No Canadian government funding.
2005
Founders of Cells for Life cord blood bank establish the Victoria Angel Registry of Hope Public Cord Blood Bank (Canada’s only public cord blood bank funded by a family bank; only public bank in Ontario).
2005
IOM completes study. Congress dedicates funds to establish a National Cord Blood Program and to increase CB medical treatment research.
2005
US Congress passes The Stem Cell Research and Therapeutic Act of 2005; allocates over $80 million to create national inventory of 150,000 CB samples. Research expands and transplant physicians are trained in use of CB stem cells.
2005
Thousands of successful CB transplants done worldwide.
2005
Use of two CB samples for adults becomes more commonplace; increasing the number of stem cells during treatment.
2005
UK researchers discover embryonic-like stem cells in CB.
2005
Researchers begin clinical trial using autologous cord blood stem cells to treat Type 1 diabetes.
2005
Researchers explore techniques to increase number of CB stem cells in one sample; enabling families to use samples for more than one treatment.
2006
US Congress distributes funds for CB research/public banking activities. State funding improves access to CB banking.
2006
Victoria Angel Registry of Hope Public Cord Blood Bank is designated as third fastest growing public bank in the world by the World Marrow Donor Association (WMDA). Still no Canadian governmental support.
2006
Research increases into the use of CB stem cells to treat Multiple Sclerosis, Alzheimer’s, Parkinson’s, Heart and Stroke, Lou Gehrig’s (ALS), spinal cord injuries, sports injuries, and other neurological/ blood/ metabolic orders.
2006
Stroke-induced mice show reduced lesion size, better neural organization and marked improvement in motor/cognitive function after CB stem cell treatment.
2006
First Cells for Life sample released to boy with leukemia; received sibling’s sample; now cured. (Hospital for Sick Children, Toronto)
2006
Cells for Life opens new laboratory and office at Toronto General Hospital. State-of-the-art facility has capacity for 125,000 samples.
2007
Children with Cerebral Palsy receiving CB transplants show marked improvement in motor function, cognitive function, eye sight and communication following cord blood stem cell transplants.
2007
CB being used to successfully treat over 70 different diseases worldwide.
2007
Duke University researchers studied 159 children with inherited metabolic disorders who received donated (unrelated) CB transplants (1995 – 2007). Study demonstrates advantages to CB use over BM transplants.
2007
Reports on the use of CB in the treatment of Parkinson’s are promising.
2007
Researcher supported by the Juvenile Diabetes Research Foundation find that transfusion of stored CB stem cells into newly diagnosed children with type 1 diabetes delays progression of disease.
2007
Study confirms 1998 findings that transplants with genetically-related CB stem cells improves outcomes compared to transplants from an unrelated donor.
2007
Cells for Life opens Montreal office near downtown hospitals.
2007
Public CB banking increases worldwide; > 400,000 samples available (> 390,000 from USA). Canada’s contribution is minimal.
2007
Canadian Provincial Health Ministers request recommendations from Canada Blood Services to develop a national public cord blood program.
2008
BBMT Article (Nietfeld et al) states that by age 70, the likelihood of needing an autologous stem cell transplant is 1 in 400; 1 in 200 for either an allogeneic or autologous transplant. (based on diseases currently treated with stem cells).
2008
Lou Gehrig’s Disease (ALS) studies with CB stem cells in mice show promising results; further research required.
2008
Study finds CB stem cell treatment increases number of neural cells and reduced inflammation in the brain in lab experiments with rats.
2008
Study finds low doses of CB stem cells in mice reduces the amount of plaques associated with Alzheimer’s Disease; increases blood flow and reduces inflammation in the brain.
2008
Cell expansion increases the number of cells in a single CB unit thereby making it more effective with larger individuals. Ongoing clinical trial studies treatment of leukemia patients with expanded CB stem cell samples; results promising.
2008
Studies in the use of CB stem cells for tissue engineering show that stem cells are capable of differentiating into cardiac tissue, as eight new heart valves were grown and tested in a laboratory setting.
2008
CB stem cell transplant performed in 2 year old boy with Epidermolysis Bullosa (fatal genetic disease caused by lack of critical protein) using sibling’s sample. Seven months after treatment, boy is producing the protein. Treatment may lead to this genetic disorder to be taken off the ‘incurable list’.
2008
Harvard School of Medicine develops fully functional blood vessels in mice by combining two types of progenitor cells including CB stem cells; may lead to a non-surgical solution in the treatment of heart disease, ischemia (reduced blood flow) and wound healing.
2009 In March 2009, US legislation was introduced called the “Family Cord Blood Banking Act” that amends the IRS Tax Code to allow parents to get tax advantages to pay for cord blood banking services. CBR Press Release, San Bruno California, March 26, 2009
2009
A total of 20 US states now legislate that health professionals must tell pregnant women of their cord blood banking options during their 2nd trimester.
2009
FDA releases guidelines for the cord blood banking industry
2010
Estimated, more than 24,000 cord blood transplants performed world wide
2011
Study finds stem cells stored for 22.5 years engrafted as expected
2011
Ministers of Health announce Canada’s first national, publicly-funded umbilical cord blood bank. Investing $48 million over the next 8 years.
This bank to be developed and managed by Canadian Blood Services.
2012
It is estimated more than 30,000 cord blood transplants performed world wide
Suggested Reading –
Explained Stem Cell Banking Cord Blood Banking Benefits of Cord Blood Banking
Reality views by sm –
Thursday, October 10, 2013
Tags – History Time Line Stem Cell Cord Blood Banking
3 comments:
Useful info. of therapeutic outlook.
@rudraprayaga
thanks.
sm, Thanks for making two detail posts explaining history and benefits of Stem Cell Cord blood banking. Last few months we tried to find more details about stem cell treatment for my relative who met accident in January, until last week she was in hospital. After spending 9 months in hospital she returns with several health problems..Two best hospitals could not do anything further so she is back home..She will rest few days but search for more treatment is still on and there is some hope in stem cell treatment.